Ⓘ ⓣⓡⓤⓛⓨ ⓛⓞⓥⓔ ⓜⓨ ☕ ⓒⓞⓕⓕⓔⓔ! Actually, my genomics test showed i am a "fast metabolizer" for coffee which means i can handle several cups in a day but I only do 1 to 2 cups at the most these days.During my residency training I would even drink it cold without sugar or creamer and could spend the entire day working, without any food but had to have my coffee. I grew up in a culture where coffee was part of our everyday life and wasn’t until i went to medical school, my love and passion for coffee started. I would honestly say was drinking way too much coffee then. Not very healthy or ideal but when you need to study extra hours each day and be awake late preparing for an exam or when i was doing my calls which had quite a lot of sleepless nights in my residency, needed to have coffee to get my day going and keep working. Would drink several cups of just plain black coffee.
.
Did you know there is a specific SNP (pronounced snip) that is called "Coffee Snp"? SNP stands for single nucleotide polymorphism. A SNP is a substitution of a single nucleotide at a specific position in the genome, that is present in a sufficiently large fraction of the population.SNPs may help predict an individual's response to certain drugs, susceptibility to environmental factors such as toxins, and risk of developing particular diseases.
.
The CYP1A2 gene codes for the CYP1A2 enzyme, which is responsible for caffeine metabolism in the liver. A particular single nucleotide polymorphism (SNP) in this gene is a major contributory factor in determining how quickly a person metabolises caffeine. People who have the C allele of this SNP are classed as being “slow” caffeine metabolizers whereas those who don’t are classed as “fast” caffeine metabolizers. Many times we have read or heard about the benefits in drinking coffee but also people may be susceptible in having side effects or have a predisposition in suffering with heart conditions due to the amount of coffee they drink. This particularly can be a problem for those who metabolize coffee more slowly. There has been studies showing people at risk for hypertension (high blood pressure) and even suffering with a MI (heart attack) having this variant and drinking too much coffee. For them, is best to limit coffee to 1 cup (or less) of coffee per day.
I was happy to know I can keep drinking my coffee without worrying about it affecting my blood pressure or making me too anxious or restless. Do you enjoy coffee as much as i do? or you cannot have one sip of it or if you do, gets your heart racing and become restless. It can be in your genes the reason why!
Some few studies to checkout!
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3482684/
https://pubmed.ncbi.nlm.nih.gov/16522833/
https://pubmed.ncbi.nlm.nih.gov/19451835/